| 英文名 |
tryptophan 2,3-dioxygenase |
| Example Structure |
 |
| 别名 |
33737, BRAFLDRAFT_210874, C28H8.11, hTDO, IDO-1, IDO-2, TDO, TDO2, TDOa, v1g157887, vCG5163, XcTDO |
| EC Number |
1.13.11.11 |
| CAS编号 |
9014-51-1 |
| Comments |
A protohemoprotein. In mammals, the enzyme appears to be located only in the liver. This enzyme, together with EC 1.13.11.52, indoleamine 2,3-dioxygenase, catalyses the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism [5]. The enzyme is specific for tryptophan as substrate, but is far more active with L-tryptophan than with D-tryptophan [2]. |
| Cofactor |
heme |
| History |
|
| Reactions |
L-tryptophan + O(2) = N-formyl-L-kynurenine. |
