| 英文名 |
tryptophan synthase (indole-salvaging) |
| Example Structure |
 |
| 别名 |
PfTrpB, PfTrpS, StTrpS (beta2), Trp synthase, TrpB2, TrpBbeta, TRPS, tryptophan synthase |
| EC Number |
4.2.1.122 |
| CAS编号 |
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| Comments |
Most mesophilic bacteria have a multimeric tryptophan synthase complex (EC?4.2.1.20) that forms?L-tryptophan from?L-serine and 1-C-(indol-3-yl)glycerol 3-phosphate via an indole intermediate. This intermediate, which is formed by the ¦Á subunits, is transferred in an internal tunnel to the ¦Â units, which convert it to tryptophan. In thermophilic organisms the high temperature enhances diffusion and causes the loss of indole. This enzyme, which does not combine with the ¦Á unit to form a complex, salvages the lost indole back to?L-tryptophan. It has a much lower Km for indole than the ¦Â subunit of EC?4.2.1.20. |
| Cofactor |
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| History |
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| Reactions |
L-serine + indole = L-tryptophan + H(2)O. |
