| 英文名 |
type I protein arginine methyltransferase |
| Example Structure |
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| 别名 |
CARM1, coactivator-associated arginine methyltransferase 1 variant 5, PRMT1, PRMT10, PRMT2, PRMT3, PRMT4, PRMT6, PRMT8, RMT1, Tb927.1.4690, Tb927.5.3960 |
| EC Number |
2.1.1.319 |
| CAS编号 |
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| Comments |
This eukaryotic enzyme catalyses the sequential dimethylation of one of the terminal guanidino nitrogen atoms in arginine residues, resulting in formation of asymmetric dimethylarginine residues. Some forms (e.g. PRMT1) have a very wide substrate specificity, while others (e.g. PRMT4 and PRMT6) are rather specific. The enzyme has a preference for methylating arginine residues that are flanked by one or more glycine residues [1]. PRMT1 is responsible for the bulk (about 85%) of total protein arginine methylation activity in mammalian cells [2]. cf. EC 2.1.1.320, type II protein arginine methyltransferase, EC 2.1.1.321, type III protein arginine methyltransferase, and EC 2.1.1.322, type IV protein arginine methyltransferase. |
| Cofactor |
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| History |
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| Reactions |
2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L- homocysteine + [protein]-N(omega),N(omega)-dimethyl-L-arginine. |
