| Comments |
The enzyme, characterized from the bacterium?Xanthomonas oryzae, catalyses epimerization of the terminal?L-glutamate in UDP-N-acetyl-¦Á-D-muramoyl-L-alanyl-L-glutamate. The reaction proceeds only in one direction and involves an adenylated intermediate. The combined activity of this enzyme and EC?6.3.2.53, UDP-N-acetylmuramoyl-L-alanine¡ªL-glutamate ligase, provides an alternative route for incorporating?D-glutamate into peptidoglycan, replacing the more common combination of EC?5.1.1.3, glutamate racemase, and EC?6.3.2.9, UDP-N-acetylmuramoyl-L-alanine¡ªD-glutamate ligase. |
