| 英文名 |
UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase |
| Example Structure |
 |
| 别名 |
Mpl, murein peptide ligase, UDP-MurNAc:L-Ala-gamma-D-Glu-meso-A2pm ligase, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase, UDP-N-alpha-D-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (ADP-forming), yjfG |
| EC Number |
6.3.2.45 |
| CAS编号 |
|
| Comments |
The enzyme catalyses the reincorporation into peptidoglycan of the tripeptide?L-alanyl-¦Ã-D-glutamyl-2,6-meso-diaminoheptanedioate released during the maturation and constant remodeling of this bacterial cell wall polymer that occur during cell growth and division. The enzyme can also use the tetrapeptide?L-alanyl-¦Ã-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanine or the pentapeptide?L-alanyl-¦Ã-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanyl-D-alanine?in vivo?and?in vitro. Requires Mg2+. |
| Cofactor |
Mg2+ |
| History |
|
| Reactions |
Atp + UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl-meso-2,6- diaminoheptanedioate = Adp + phosphate + UDP-N-acetylmuramoyl-L-alanyl- gamma-D-glutamyl-meso-2,6-diaminoheptanedioate. |
