| 英文名 |
UDP-N,N’-diacetylbacillosamine 2-epimerase (hydrolysing) |
| Example Structure |
 |
| 别名 |
Cj1328, LeG, neuC, UDP-Bac2Ac4Ac 2-epimerase, UDP-N-acetylglucosamine 2-epimerase |
| EC Number |
3.2.1.184 |
| CAS编号 |
|
| Comments |
Requires Mg2+. Involved in biosynthesis of legionaminic acid, a nonulosonate derivative that is incorporated by some bacteria into assorted virulence-associated cell surface glycoconjugates. The initial product formed by the enzyme from?Legionella pneumophila, which incorporates legionaminic acid into the O-antigen moiety of its lipopolysaccharide, is 2,4-diacetamido-2,4,6-trideoxy-¦Á-D-mannopyranose, which rapidly mutarotates to a mixture of anomers [1]. The enzyme from?Campylobacter jejuni, which incorporates legionaminic acid into flagellin, prefers GDP-N,N’-diacetylbacillosamine [2]. |
| Cofactor |
Mg2+ |
| History |
|
| Reactions |
UDP-N,N’-diacetylbacillosamine + H(2)O = Udp + 2,4-diacetamido-2,4,6- trideoxy-D-mannopyranose. |
