| 英文名 |
uracil/thymine dehydrogenase |
| Example Structure |
 |
| 别名 |
dehydrogenase, uracil, EC 1.1.99.19, EC 1.2.99.1, uracil dehydrogenase, uracil oxidase, uracil-thymidine oxidase |
| EC Number |
1.17.99.4 |
| CAS编号 |
9029-00-9 |
| Comments |
Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 3.5.2.1 (barbiturase) and EC 3.5.1.95 (N-malonylurea hydrolase). Mammals, plants and other microorganisms utilize the reductive pathway, comprising EC 1.3.1.1 [dihydrouracil dehydrogenase (NAD+)] or EC 1.3.1.2 [dihydropyrimidine dehydrogenase (NADP+)], EC 3.5.2.2 (dihydropyrimidinase) and EC 3.5.1.6 (¦Â-ureidopropionase), with the ultimate degradation products being an L-amino acid, NH3 and CO2 [5]. Formerly EC 1.2.99.1. |
| Cofactor |
|
| History |
|
| Reactions |
(1) Uracil + H(2)O + acceptor = barbiturate + reduced acceptor. (2) Thymine + H(2)O + acceptor = 5-methylbarbiturate + reduced acceptor. |
