| 英文名 |
uridine-5′-phosphate dioxygenase |
| Example Structure |
 |
| 别名 |
alpha-ketoglutarate:UMP dioxygenase, alpha-KG:UMP dioxygenase, LIPL, UMP:alpha-ketoglutarate dioxygenase, uridine-5-monophosphate alpha-ketoglutarate dioxygenase |
| EC Number |
1.14.11.49 |
| CAS编号 |
|
| Comments |
The enzyme catalyses a net dephosphorylation and oxidation of UMP to generate 5′-dehydrouridine, the first intermediate in the biosynthesis of the unusual aminoribosyl moiety found in several C7-furanosyl nucleosides such as A-90289s, caprazamycins, liposidomycins, muraymycins and FR-900453. Requires Fe2+. |
| Cofactor |
Fe2+ |
| History |
|
| Reactions |
Ump + 2-oxoglutarate + O(2) = 5′-dehydrouridine + succinate + CO(2) + phosphate. |
