| 英文名 |
Xaa-Xaa-Pro tripeptidyl-peptidase |
| Example Structure |
 |
| 别名 |
prolyl tripeptidyl aminopeptidase, prolyl tripeptidyl peptidase, prolyltripeptidyl aminopeptidase, PTP, PTP39 |
| EC Number |
3.4.14.12 |
| CAS编号 |
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| Comments |
This cell-surface-associated serine exopeptidase is found in the Gram-negative, anaerobic bacterium?Porphyromonas gingivalis, which has been implicated in adult periodontal disease [1]. The enzyme releases tripeptides from the free amino terminus of peptides and small proteins, such as interleukin 6. The enzyme possesses an absolute requirement for a proline residue at the P1 position but is completely inactivated by a proline residue at the P1′ position [1]. The size of the peptide does not affect the rate of reaction [1]. |
| Cofactor |
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| History |
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| Reactions |
Hydrolysis of Xaa-Xaa-Pro-|-Yaa- releasing the N-terminal tripeptide of a peptide with Pro as the third residue (position P1) and where Yaa is not proline. |
